Characterizing soluble immune checkpoint molecules and TGF-β_1,2,3 in pleural effusion of malignant pleural mesothelioma.

ABSTRACT: The clinical impact of soluble molecules in pleural effusion (PE) is unclear in patients with malignant pleural mesothelioma (MPM). In this single-center, retrospective, observational study, we assessed soluble forms of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death protein 1 (PD-1), and PD-1 ligand 1 (PD-L1) using enzyme-linked immunosorbent assays; three TGF-β isoforms were measured via multiplex assay in PE of patients with fibrinous pleuritis (FP) or MPM, to assess relationships between the levels of six molecules, clinicopathological characteristics, and efficacy of immune checkpoint inhibitors. Soluble forms of CTLA-4, PD-L1, PD-1, TGF-β₁, TGF-β₂, and TGF-β₃ were variably produced in PE of FP (n = 34) and MPM (n = 79); we

SUBMITTER: Okita R 

PROVIDER: S-EPMC11236966 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature