Prognostic value of Maspin protein level in patients with triple negative breast cancer.

ABSTRACT: The search for prognostic markers in breast cancer has bumped into a typical feature of these tumors, intra and intertumoral heterogeneity. Changes in the expression profile, localization of these proteins or shedding to the surrounding stroma can be useful in the search for new markers. In this context, classification by molecular subtypes can bring perspectives for both diagnosis and screening for appropriate treatments. However, the Triple Negative (TN) subtype, which is already the one with the worst prognosis, lacks appropriate and consistent molecular markers. In this work, we analyzed 346 human breast cancer samples in tissue microarrays (TMA) from cases diagnosed with invasive breast carcinoma to assess the expression and localization pattern of Maspin and their correlation with cl

SUBMITTER: do Nascimento RG 

PROVIDER: S-EPMC11237076 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature