A mixed meal tolerance test predicts onset of type 2 diabetes in Southwestern Indigenous adults.

ABSTRACT:

Background/objective

To identify predictors of incident type 2 diabetes using a mixed meal tolerance test (MMTT).

Methods

Adult Indigenous Americans without diabetes (n = 501) from a longitudinal cohort underwent at baseline a 4-h MMTT, measures of body composition, an oral glucose tolerance test, an intravenous glucose tolerance test for acute insulin response (AIR), and a hyperinsulinemic-euglycemic clamp for insulin action (M). Plasma glucose responses from the MMTT were quantified by the total and incremental area under the curve (AUC/iAUC).

Results

At follow-up (median time 9.6 [inter-quartile range: 5.6-13.5] years), 169 participants were diagnosed with diabetes. Unadjusted Cox proportional hazards models, glucose AUC_180-min (HR: 1.98, 95% CI: 1.67, 2

SUBMITTER: Mitchell CM 

PROVIDER: S-EPMC11237083 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature