Histamine H₁ receptors in dentate gyrus-projecting cholinergic neurons of the medial septum suppress contextual fear retrieval in mice.

ABSTRACT: Fear memory is essential for survival and adaptation, yet excessive fear memories can lead to emotional disabilities and mental disorders. Despite previous researches have indicated that histamine H₁ receptor (H₁R) exerts critical and intricate effects on fear memory, the role of H₁R is still not clarified. Here, we show that deletion of H₁R gene in medial septum (MS) but not other cholinergic neurons selectively enhances contextual fear memory without affecting cued memory by differentially activating the dentate gyrus (DG) neurons in mice. H₁R in cholinergic neurons mediates the contextual fear retrieval rather than consolidation by decreasing acetylcholine release pattern in DG. Furthermore, selective knockdown of H₁R in

SUBMITTER: Cheng L 

PROVIDER: S-EPMC11237085 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature