Development of a mouse model of chronic ventral spinal cord compression: Neurobehavioral, radiological, and pathological changes.

ABSTRACT:

Objectives

The main objective of this study was to establish a mouse model of spinal ligament ossification to simulate the chronic spinal cord compression observed in patients with ossification of the posterior longitudinal ligament (OPLL). The study also aimed to examine the mice's neurobiological, radiological, and pathological changes.

Methods

In the previous study, a genetically modified mouse strain was created using Crispr-Cas9 technology, namely, Enpp1 ^flox/flox /EIIa-Cre (C57/B6 background), to establish the OPLL model. Wild-type (WT) mice without compression were used as controls. Functional deficits were evaluated through motor score assessment, inclined plate testing, and gait analysis. The extent of compression was determined using

SUBMITTER: He Z 

PROVIDER: S-EPMC11237184 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature