Genome-scale model of Rothia mucilaginosa predicts gene essentialities and reveals metabolic capabilities.

ABSTRACT: Cystic fibrosis (CF), an inherited genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator gene, results in sticky and thick mucosal fluids. This environment facilitates the colonization of various microorganisms, some of which can cause acute and chronic lung infections, while others may positively impact the disease. Rothia mucilaginosa, an oral commensal, is relatively abundant in the lungs of CF patients. Recent studies have unveiled its anti-inflammatory properties using in vitro three-dimensional lung epithelial cell cultures and in vivo mouse models relevant to chronic lung diseases. Apart from this, R. mucilaginosa has been associated with severe infections. However, its metabolic capabilities and genotype-phenotyp

SUBMITTER: Leonidou N 

PROVIDER: S-EPMC11237427 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature