The phage shock protein (PSP) envelope stress response: discovery of novel partners and evolutionary history.

ABSTRACT: Bacterial phage shock protein (PSP) systems stabilize the bacterial cell membrane and protect against envelope stress. These systems have been associated with virulence, but despite their critical roles, PSP components are not well characterized outside proteobacteria. Using comparative genomics and protein sequence-structure-function analyses, we systematically identified and analyzed PSP homologs, phyletic patterns, domain architectures, and gene neighborhoods. This approach underscored the evolutionary significance of the system, revealing that its core protein PspA (Snf7 in ESCRT outside bacteria) was present in the last universal common ancestor and that this ancestral functionality has since diversified into multiple novel, distinct PSP systems across life. Several novel partners of

SUBMITTER: Ravi J 

PROVIDER: S-EPMC11237479 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature