Selective bacteriophages reduce the emergence of resistant bacteria in bacteriophage-antibiotic combination therapy.

ABSTRACT: Escherichia coli O157:H7 is a globally important foodborne pathogen with implications for food safety. Antibiotic treatment for O157 may potentially contribute to the exacerbation of hemolytic uremic syndrome, and the increasing prevalence of antibiotic-resistant strains necessitates the development of new treatment strategies. In this study, the bactericidal effects and resistance development of antibiotic and bacteriophage monotherapy were compared with those of combination therapy against O157. Experiments involving continuous exposure of O157 to phages and antibiotics, along with genetic deletion studies, revealed that the deletion of glpT and uhpT significantly increased resistance to fosfomycin. Furthermore, we found that OmpC functions as a receptor for the PP01

SUBMITTER: Azam AH 

PROVIDER: S-EPMC11237537 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature