Seasonality of respiratory, enteric, and urinary viruses revealed by wastewater genomic surveillance.

ABSTRACT: Wastewater surveillance can reveal population-level infectious disease burden and emergent public health threats can be reliably assessed through wastewater surveillance. While molecular methods for wastewater monitoring of microorganisms have traditionally relied on PCR-based approaches, next-generation sequencing (NGS) can provide deeper insights via genomic analyses of multiple diverse pathogens. We conducted a year-long sequencing surveillance of 1,408 composite wastewater samples collected from 12 neighborhood-level access points in the greater Tempe area, Arizona, USA, and show that variation in wastewater viruses is driven by seasonal time and location. The temporal dynamics of viruses in wastewater were influenced cyclically, with the most dissimilarity between samples 23 weeks apa

SUBMITTER: Smith MF 

PROVIDER: S-EPMC11237574 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature