First report of the chromosomal integration of carbapenemase gene bla_IMP-19 in Acinetobacter baumannii AB322: the legacy of integron in phage-plasmid?

ABSTRACT: Integration of carbapenemase gene bla_IMP into the chromosome of carbapenem-resistant Acinetobacter baumannii (CRAB) has not been reported. The aim of this study was to explore the genomic characteristics of CRAB AB322 isolated from a Taiwanese patient diagnosed with bacteremia in 2011, whose chromosome harbors bla_IMP-19. Disk diffusion and broth microdilution were employed to analyze the antimicrobial susceptibility of AB322 to 14 antimicrobials. Nanopore whole-genome sequencing platform was utilized for AB322 genome sequencing, and conjugation was further performed to investigate the transferability of bla_IMP-19 to amikacin-resistant A. baumannii 218 (AB218) and Acinetobacter nosocomialis 254 (AN254). The results s

SUBMITTER: Shih Y-L 

PROVIDER: S-EPMC11237583 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature