Role of ethanolamine utilization and bacterial microcompartment formation in <i>Listeria monocytogenes</i> intracellular infection.

ABSTRACT: Ethanolamine (EA) affects the colonization and pathogenicity of certain human bacterial pathogens in the gastrointestinal tract. However, EA can also affect the intracellular survival and replication of host cell invasive bacteria such as Listeria monocytogenes (LMO) and Salmonella enterica serovar Typhimurium (S. Typhimurium). The EA utilization (eut) genes can be categorized as regulatory, enzymatic, or structural, and previous work in LMO showed that loss of genes encoding functions for the enzymatic breakdown of EA inhibited LMO intracellular replication. In this work, we sought to further characterize the role of EA utilization during LMO infection of host cells. Unlike what was previously observed for S. Typhimurium, in LMO, an EA regulator mutant (

SUBMITTER: Chatterjee A 

PROVIDER: S-EPMC11237587 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature