GDP-mannose pyrophosphorylase is an efficient target in Xanthomonas citri for citrus canker control.

ABSTRACT: Xanthomonas citri subsp. citri (Xcc) is a bacterium that causes citrus canker, an economically important disease that results in premature fruit drop and reduced yield of fresh fruit. In this study, we demonstrated the involvement of XanB, an enzyme with phosphomannose isomerase (PMI) and guanosine diphosphate-mannose pyrophosphorylase (GMP) activities, in Xcc pathogenicity. Additionally, we found that XanB inhibitors protect the host against Xcc infection. Besides being deficient in motility, biofilm production, and ultraviolet resistance, the xanB deletion mutant was unable to cause disease, whereas xanB complementation restored wild-type phenotypes. XanB homology modeling allowed in silico virtual screening of inhibitors from databases, three of them b

SUBMITTER: Alexandrino AV 

PROVIDER: S-EPMC11237706 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature