Novel antimony-based antimicrobial drug targets membranes of Gram-positive and Gram-negative bacterial pathogens.

ABSTRACT: Antimicrobial resistance (AMR) poses a significant worldwide public health crisis that continues to threaten our ability to successfully treat bacterial infections. With the decline in effectiveness of conventional antimicrobial therapies and the lack of new antibiotic pipelines, there is a renewed interest in exploring the potential of metal-based antimicrobial compounds. Antimony-based compounds with a long history of use in medicine have re-emerged as potential antimicrobial agents. We previously synthesized a series of novel organoantimony(V) compounds complexed with cyanoximates with a strong potential of antimicrobial activity against several AMR bacterial and fungal pathogens. Here, five selected compounds were studied for their antibacterial efficacy against three important bacteri

SUBMITTER: Salpadoru T 

PROVIDER: S-EPMC11237720 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature