Infection-associated gene regulation of L-tartrate metabolism in Salmonella enterica serovar Typhimurium.

ABSTRACT: Enteric pathogens such as Salmonella enterica serovar Typhimurium experience spatial and temporal changes to the metabolic landscape throughout infection. Host reactive oxygen and nitrogen species non-enzymatically convert monosaccharides to alpha hydroxy acids, including L-tartrate. Salmonella utilizes L-tartrate early during infection to support fumarate respiration, while L-tartrate utilization ceases at later time points due to the increased availability of exogenous electron acceptors such as tetrathionate, nitrate, and oxygen. It remains unknown how Salmonella regulates its gene expression to metabolically adapt to changing nutritional environments. Here, we investigated how the transcriptional regulation for L-tartrate metabolism in Salmonella is influenc

SUBMITTER: Rojas VK 

PROVIDER: S-EPMC11237755 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature