Adaptive attenuation of virulence in hypervirulent carbapenem-resistant Klebsiella pneumoniae.

ABSTRACT: The emergence of nosocomial infections caused by hypervirulent and carbapenem-resistant K. pneumoniae (hv-CRKP) has become a significant public health challenge. The genetic traits of virulence and resistance plasmids in hv-CRKP have been extensively studied; however, research on the adaptive evolution strategies of clinical strains inside the host was scarce. This study aimed to understand the effects of antibiotic treatment on the phenotype and genotype characteristics of hv-CRKP. We investigated the evolution of hv-CRKP strains isolated from the same patient to elucidate the transition between hospital invasion and colonization. A comparative genomics analysis was performed to identify single nucleotide polymorphisms in the rmpA promoter. Subsequent validation through RNA-

SUBMITTER: Teng G 

PROVIDER: S-EPMC11237801 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature