Myofiber-specific lipidomics unveil differential contributions to insulin sensitivity in individuals of African and European ancestry.

ABSTRACT:

Aims

Individuals of African ancestry (AA) present with lower insulin sensitivity compared to their European counterparts (EA). Studies show ethnic differences in skeletal muscle fiber type (lower type I fibers in AA), muscle fat oxidation capacity (lower in AA), whilst no differences in total skeletal muscle lipids. However, skeletal muscle lipid subtypes have not been examined in this context. We hypothesize that lower insulin sensitivity in AA is due to a greater proportion of type II (non-oxidative) muscle fibers, and that this would result in an ancestry-specific association between muscle lipid subtypes and peripheral insulin sensitivity. To test this hypothesis, we examined the association between insulin sensitivity and muscle lipids in AA and EA adults, and in an animal mod

SUBMITTER: Euren T 

PROVIDER: S-EPMC11237840 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature