Gravidity influences distinct transcriptional profiles of maternal and fetal placental macrophages at term.

ABSTRACT:

Introduction

Maternal intervillous monocytes (MIMs) and fetal Hofbauer cells (HBCs) are myeloid-derived immune cells at the maternal-fetal interface. Maternal reproductive history is associated with differential risk of pregnancy complications. The molecular phenotypes and roles of these distinct monocyte/macrophage populations and the influence of gravidity on these phenotypes has not been systematically investigated.

Methods

Here, we used RNA sequencing to study the transcriptional profiles of MIMs and HBCs in normal term pregnancies.

Results

Our analyses revealed distinct transcriptomes of MIMs and HBCs. Genes involved in differentiation and cell organization pathways were more highly expressed in MIMs vs. HBCs. In contrast, HBCs had higher expression of genes invo

SUBMITTER: Ozarslan N 

PROVIDER: S-EPMC11237841 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature