T cell hybrid immunity against SARS-CoV-2 in children: a longitudinal study.

ABSTRACT:

Background

Hybrid immunity to SARS-CoV-2, resulting from both vaccination and natural infection, remains insufficiently understood in paediatric populations, despite increasing rates of breakthrough infections among vaccinated children.

Methods

We conducted a prospective longitudinal study to investigate the magnitude, specificity, and cytokine profile of antigen-specific T cell responses elicited by breakthrough SARS-CoV-2 infection in a cohort of mRNA-vaccinated children (n = 29) aged 5-11. This longitudinal analysis involved six distinct time points spanning a 16-month period post-vaccination, during which we analysed a total of 159 blood samples. All children who were followed for at least 12 months (n = 26) experienced a breakthrough infection. We conducted cytokine rel

SUBMITTER: Qui M 

PROVIDER: S-EPMC11237860 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature