Tumour-specific activation of a tumour-blood transport improves the diagnostic accuracy of blood tumour markers in mice.

ABSTRACT:

Background

The accuracy of blood-based early tumour recognition is compromised by signal production at non-tumoral sites, low amount of signal produced by small tumours, and variable tumour production. Here we examined whether tumour-specific enhancement of vascular permeability by the particular tumour homing peptide, iRGD, which carries dual function of binding to integrin receptors overexpressed in the tumour vasculature and is known to promote extravasation via neuropilin-1 receptor upon site-specific cleavage, might be useful to improve blood-based tumour detection by inducing a yet unrecognised vice versa tumour-to-blood transport.

Methods

To detect an iRGD-induced tumour-to-blood transport, we examined the effect of intravenously injected iRGD on blood levels of α-fet

SUBMITTER: Schmithals C 

PROVIDER: S-EPMC11237870 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature