Early Cardiac Effects of Contemporary Radiation Therapy in Patients With Breast Cancer.

ABSTRACT:

Purpose

To characterize the early changes in echocardiographically derived measures of cardiac function with contemporary radiation therapy (RT) in breast cancer and to determine the associations with radiation dose-volume metrics, including mean heart dose (MHD).

Methods and materials

In a prospective longitudinal cohort study of 86 patients with breast cancer treated with photon or proton thoracic RT, clinical and echocardiographic data were assessed at 3 time points: within 4 weeks before RT initiation (T0), within 3 days before 6 weeks after the end of RT (T1), and 5 to 9 months after RT completion (T2). Associations between MHD and echocardiographically derived measures of cardiac function were assessed using generalized estimating equations to define the acute (T0 to T

SUBMITTER: Clasen SC 

PROVIDER: S-EPMC11237872 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature