The Left-Right Side-Specific Neuroendocrine Signaling from Injured Brain: An Organizational Principle.

ABSTRACT: A neurological dogma is that the contralateral effects of brain injury are set through crossed descending neural tracts. We have recently identified a novel topographic neuroendocrine system (T-NES) that operates via a humoral pathway and mediates the left-right side-specific effects of unilateral brain lesions. In rats with completely transected thoracic spinal cords, unilateral injury to the sensorimotor cortex produced contralateral hindlimb flexion, a proxy for neurological deficit. Here, we investigated in acute experiments whether T-NES consists of left and right counterparts and whether they differ in neural and molecular mechanisms. We demonstrated that left- and right-sided hormonal signaling is differentially blocked by the δ-, κ- and µ-opioid antagonists. Left and right neurohor

SUBMITTER: Watanabe H 

PROVIDER: S-EPMC11237900 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature