Comparative genome analyses of clinical and non-clinical Clostridioides difficile strains.

ABSTRACT: The pathogenic bacterium Clostridioides difficile is a worldwide health burden with increasing morbidity, mortality and antibiotic resistances. Therefore, extensive research efforts are made to unravel its virulence and dissemination. One crucial aspect for C. difficile is its mobilome, which for instance allows the spread of antibiotic resistance genes (ARG) or influence strain virulence. As a nosocomial pathogen, the majority of strains analyzed originated from clinical environments and infected individuals. Nevertheless, C. difficile can also be present in human intestines without disease development or occur in diverse environmental habitats such as puddle water and soil, from which several strains could already be isolated. We therefore performed comprehensive gen

SUBMITTER: Schuler MA 

PROVIDER: S-EPMC11238072 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature