Infliximab inhibits TNF-α-dependent activation of the NLRP3/IL-1β pathway in acne inversa.

ABSTRACT:

Background

Acne inversa (AI) is a refractory inflammatory skin disease, and TNF-α plays an important role in the pathogenesis of AI. By blocking TNF-α, infliximab (IFX) has been proven to be a promising method.

Objectives

To explore the underlying mechanisms of IFX treatment in AI patients.

Methods

In this research, we integrated transcriptome sequencing data from the samples of our patients with AI and the GEO database. Ex vivo skin culture of AI patients was conducted to evaluate the efficacy of IFX treatment. Animal studies and cell experiments were used to explore the therapeutic effect and mechanism of IFX treatment.

Results

Both TNF-α and NLRP3 inflammasome-related pathways were enriched in skin lesions of AI patients and murine AI models. After IF

SUBMITTER: He Y 

PROVIDER: S-EPMC11238120 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature