Electroless Ionization Mass Spectrometry Using a Compact Electrokinetic Ionization Source.

ABSTRACT: We introduce a new ionization technique for compact, portable mass spectrometers. It consists of a syringe with sample liquid capped by a self-ionizing spray nozzle containing a microfabricated nozzle chip. Interaction of the sample liquid with the nozzle wall results in electrical charging without the need for electronics. Elaborate cleaning procedures are redundant when disposable syringes and mass-fabricated spray nozzles are used. This self-named electroless spray ionization (ELI) technique shows comparable performance to conventional ionization techniques. In contrast to commonly used electrospray ionization, ELI exhibits excellent ionization efficiency for low-conductive solutions such as water or acetonitrile. Due to its compact size and the absence of high-voltage electronics, it c

SUBMITTER: Kooij S 

PROVIDER: S-EPMC11238159 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature