Deciphering maternal-fetal cross-talk in the human placenta during parturition using single-cell RNA sequencing.

ABSTRACT: Labor is a complex physiological process requiring a well-orchestrated dialogue between the mother and fetus. However, the cellular contributions and communications that facilitate maternal-fetal cross-talk in labor have not been fully elucidated. Here, single-cell RNA sequencing (scRNA-seq) was applied to decipher maternal-fetal signaling in the human placenta during term labor. First, a single-cell atlas of the human placenta was established, demonstrating that maternal and fetal cell types underwent changes in transcriptomic activity during labor. Cell types most affected by labor were fetal stromal and maternal decidual cells in the chorioamniotic membranes (CAMs) and maternal and fetal myeloid cells in the placenta. Cell-cell interaction analyses showed that CAM and placental cell typ

SUBMITTER: Garcia-Flores V 

PROVIDER: S-EPMC11238316 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature