Crafting Stable Antibiotic Nanoparticles via Complex Coacervation of Colistin with Block Copolymers.

ABSTRACT: To combat the ever-growing increase of multidrug-resistant (MDR) bacteria, action must be taken in the development of antibiotic formulations. Colistin, an effective antibiotic, was found to be nephrotoxic and neurotoxic, consequently leading to a ban on its use in the 1980s. A decade later, colistin use was revived and nowadays used as a last-resort treatment against Gram-negative bacterial infections, although highly regulated. If cytotoxicity issues can be resolved, colistin could be an effective option to combat MDR bacteria. Herein, we investigate the complexation of colistin with poly(ethylene oxide)-b-poly(methacrylic acid) (PEO-b-PMAA) block copolymers to form complex coacervate core micelles (C3Ms) to ultimately improve colistin use in therapeutics while maintaining

SUBMITTER: Vogelaar TD 

PROVIDER: S-EPMC11238337 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature