MiRNAs: possible regulators of toll like receptors and inflammatory tumor microenvironment in colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is ranked as the third most commonly diagnosed cancer and the third cause of cancer related deaths. CRC is greatly attributed to genetic and epigenetic mutations and immune dysregulation. Tumor aberrant expression of Toll-like Receptors (TLRs) can contribute to tumorigenesis. Recent studies suggested that microRNAs act as direct ligands of TLRs altering their expression and signaling pathways.

Aim

To prove our concept that specific miRNA mimics may act as antagonists of their specific toll like receptors inhibiting their expression that could limit the release of pro-inflammatory and pro-tumorigenic cytokines leading to apoptosis of tumor cells.

Methods

From public microarray databases, we retrieved TLRs and miRNAs related to CRC fol

SUBMITTER: Matboli M 

PROVIDER: S-EPMC11238347 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature