Identification of Babesia microti immunoreactive antigens by phage display cDNA screen.

ABSTRACT: Human babesiosis is a malaria-like illness caused by protozoan parasites of the genus Babesia. Babesia microti is responsible for most cases of human babesiosis in the United States, particularly in the Northeast and the Upper Midwest. Babesia microti is primarily transmitted to humans through the bite of infected deer ticks but also through the transfusion of blood components, particularly red blood cells. There is a high risk of severe and even fatal disease in immunocompromised patients. To date, serology testing relies on an indirect immunofluorescence assay that uses the whole Babesia microti antigen. Here, we report the construction of phage display cDNA libraries from Babesia microti-infected erythrocytes as well as human reticulocytes obtained fro

SUBMITTER: Hanada T 

PROVIDER: S-EPMC11238553 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature