The atypical antipsychotic aripiprazole alters the outcome of disseminated Candida albicans infections.

ABSTRACT: Invasive fungal infections impose an enormous clinical, social, and economic burden on humankind. One of the most common species responsible for invasive fungal infections is Candida albicans. More than 30% of patients with disseminated candidiasis fail therapy with existing antifungal drugs, including the widely used azole class. We previously identified a collection of 13 medications that antagonize the activity of the azoles on C. albicans. Although gain-of-function mutations responsible for antifungal resistance are often associated with reduced fitness and virulence, it is currently unknown how exposure to azole antagonistic drugs impacts C. albicans physiology, fitness, or virulence. In this study, we examined how exposure to seven azole antagonists affects C.

SUBMITTER: Reitler P 

PROVIDER: S-EPMC11238555 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature