Investigating the importance of selected surface-exposed loops in HpuB for hemoglobin binding and utilization by <i>Neisseria gonorrhoeae</i>.

ABSTRACT: Neisseria gonorrhoeae is the etiological agent of the sexually transmitted infection gonorrhea. The pathogen is a global health challenge since no protective immunity results from infection, and far fewer treatment options are available with increasing antimicrobial resistance. With no efficacious vaccines, researchers are exploring new targets for vaccine development and innovative therapeutics. The outer membrane TonB-dependent transporters (TdTs) produced by N. gonorrhoeae are considered promising vaccine antigens as they are highly conserved and play crucial roles in overcoming nutritional immunity. One of these TdTs is part of the hemoglobin transport system comprised of HpuA and HpuB. This system allows N. gonorrhoeae to acquire iron from hemoglobin (hHb). In the

SUBMITTER: Awate OA 

PROVIDER: S-EPMC11238557 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature