α-Synuclein Oligomers Displace Monomeric α-Synuclein from Lipid Membranes.

ABSTRACT: Parkinson's disease (PD) is an increasingly prevalent and currently incurable neurodegenerative disorder linked to the accumulation of α-synuclein (αS) protein aggregates in the nervous system. While αS binding to membranes in its monomeric state is correlated to its physiological role, αS oligomerization and subsequent aberrant interactions with lipid bilayers have emerged as key steps in PD-associated neurotoxicity. However, little is known of the mechanisms that govern the interactions of oligomeric αS (OαS) with lipid membranes and the factors that modulate such interactions. This is in large part due to experimental challenges underlying studies of OαS-membrane interactions due to their dynamic and transient nature. Here, we address this challenge by using a suite of microfluidics-bas

SUBMITTER: Sneideriene G 

PROVIDER: S-EPMC11238581 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature