Associations between prenatal metal and metalloid mixtures in teeth and reductions in childhood lung function.

ABSTRACT:

Background

Metal(oid)s have been cross-sectionally associated with lung function outcomes in childhood but there is limited data on their combined effects starting in utero. Child sex may further modify these effects.

Objective

Examine associations between in utero and early life exposure to metals assessed via novel dentine biomarkers and childhood lung function and explore effect modification by child sex.

Methods

Analyses included 291 children enrolled in the Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS) study, a longitudinal birth cohort study in Mexico City. Weekly dentine levels of arsenic (As), cadmium (Cd), cobalt (Co), copper (Cu), manganese (Mn), nickel (Ni), and lead (Pb) were measured from 15 weeks pre-birth to 15 wee

SUBMITTER: Rosa MJ 

PROVIDER: S-EPMC11238599 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature