From bone to nanoparticles: development of a novel generation of bone derived nanoparticles for image guided orthopedic regeneration.

ABSTRACT: Bone related diseases such as osteoporosis, osteoarthritis, metastatic bone cancer, osteogenesis imperfecta, and Paget's disease, are primarily treated with pharmacologic therapies that often exhibit limited efficacy and substantial side effects. Bone injuries or fractures are primarily repaired with biocompatible materials that produce mixed results in sufficiently regenerating healthy and homogenous bone tissue. Each of these bone conditions, both localized and systemic, use different strategies with the same goal of achieving a healthy and homeostatic bone environment. In this study, we developed a new type of bone-based nanoparticle (BPs) using the entire organic extracellular matrix (ECM) of decellularized porcine bone, additionally encapsulating indocyanine green dye (ICG) for an

SUBMITTER: Stellpflug A 

PROVIDER: S-EPMC11238765 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature