<i>Helicobacter pylori</i> East Asian type CagA hijacks more SHIP2 by its EPIYA-D motif to potentiate the oncogenicity.

ABSTRACT: CagA is a significant oncogenic factor injected into host cells by Helicobacter pylori, which is divided into two subtypes: East Asian type (CagA^E), characterized by the EPIYA-D motif, and western type (CagA^W), harboring the EPIYA-C motif. CagA^E has been reported to have higher carcinogenicity than CagA^W, although the underlying reason is not fully understood. SHIP2 is an intracellular phosphatase that can be recruited by CagA to perturb the homeostasis of intracellular signaling pathways. In this study, we found that SHIP2 contributes to the higher oncogenicity of CagA^E. Co-Immunoprecipitation and Pull-down assays showed that CagA^E bind more SHIP2 than CagA^W. Immunofluorescence staining showed that a highe

SUBMITTER: Ji X 

PROVIDER: S-EPMC11238919 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature