Migraine and gastroesophageal reflux disease: Disentangling the complex connection with depression as a mediator.

ABSTRACT:

Objective

Gastroesophageal reflux disease (GERD) and migraine are public health concerns worldwide. No observational study has conclusively elucidated the causal relationship between these two conditions. We employed Mendelian randomization (MR) methods to explore the potential causal links between GERD and migraine.

Methods

Genome-wide association studies were subjected to MR to infer the causality between GERD and migraine. Bidirectional two-sample MR was performed to establish causal relationships. Multivariable MR analysis was conducted to adjust potential confounding factors, and mediation MR analysis was utilized to assess the role of depression between GERD and migraine as a mediator. We primarily utilized the inverse variance weighted method (IVW) and sensitivity ana

SUBMITTER: Shen Z 

PROVIDER: S-EPMC11239078 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature