Distinct anal microbiome is correlated with anal cancer precursors in MSM with HIV.

ABSTRACT:

Objectives

Anal cancer risk is elevated in MSM with HIV (MSMWH). Anal high-risk human papillomavirus (hr-HPV) infection is necessary but insufficient to develop high-grade squamous intraepithelial lesion (HSIL), the anal cancer precursor, suggesting additional factors. We sought to determine whether the microbiome of the anal canal is distinct by comparing it with the microbiome of stool. We also sought to determine whether changes in the anal microbiome are associated with HSIL among MSMWH.

Design

Cross-sectional comparison of the microbiome of the anal canal with the microbiome of stool in MSMWH and cross-sectional comparison of the anal microbiome of MSMWH with anal HSIL with the anal microbiome of MSMWH without anal HSIL.

Methods

Sterile swabs were used to sample

SUBMITTER: Brickman CE 

PROVIDER: S-EPMC11239087 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature