Descriptive molecular pharmacology of the δ opioid receptor (DOR): A computational study with structural approach.

ABSTRACT: This work focuses on the δ receptor (DOR), a G protein-coupled receptor (GPCR) belonging to the opioid receptor group. DOR is expressed in numerous tissues, particularly within the nervous system. Our study explores computationally the receptor's interactions with various ligands, including opiates and opioid peptides. It elucidates how these interactions influence the δ receptor response, relevant in a wide range of health and pathological processes. Thus, our investigation aims to explore the significance of DOR as an incoming drug target for pain relief and neurodegenerative diseases and as a source for novel opioid non-narcotic analgesic alternatives. We analyze the receptor's structural properties and interactions using Molecular Dynamics (MD) simulations and Gaussian-accelerated MD a

SUBMITTER: Goode-Romero G 

PROVIDER: S-EPMC11239112 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature