CCL14 Predicts Oliguria and Dialysis Requirement in Patients with Moderate to Severe Acute Kidney Injury.

ABSTRACT:

Introduction

AKI is a frequent complication of critical illness and portends poor outcome. CCL14 is a validated predictor of persistent severe AKI in critically ill patients. We examined the association of CCL14 with urine output within 48 h.

Methods

In pooled data from 2 studies of critically ill patients with KDIGO stage 2-3 AKI, CCL14 was measured by NEPHROCLEAR™ CCL14 Test on the Astute 140® Meter (low, intermediate, and high categories [1.3 and 13 ng/mL]). Average hourly urine output over 48 h, stage 3 AKI per urine output criterion on day 2, and composite of dialysis or death within 7 days were examined using multivariable mixed and logistic regression models.

Results

Of the 497 subjects with median age of 65 (56-74) years, 49% (242/497) were on diuretics. CCL14

SUBMITTER: Demirjian S 

PROVIDER: S-EPMC11239143 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature