Monitoring levetiracetam concentration in saliva during pregnancy is stable and feasible.

ABSTRACT:

Aims

This multicenter prospective cohort study (registration no. ChiCTR2000032089) aimed to investigate the relationship between saliva and plasma levetiracetam concentrations to determine whether saliva could be used for routine monitoring of levetiracetam during pregnancy.

Methods

The slot concentrations of levetiracetam in simultaneously obtained saliva and plasma samples were measured using UPLC-MS/MS. The correlations between saliva and plasma levetiracetam concentrations and the dose-normalized concentrations were compared among pregnant women in different stages and nonpregnant control participants with epilepsy.

Results

In total, 231 patients with 407 plasma and saliva sample pairs were enrolled from 39 centers. Linear relationships between salivary and plasma

SUBMITTER: Li W 

PROVIDER: S-EPMC11239326 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature