PO₂ reporter composite hydrogel macroencapsulation devices for magnetic resonance imaging oxygen quantification.

ABSTRACT: Hydrogel cell encapsulation devices are a common approach to reduce the need for chronic systemic immunosuppression in allogeneic cell product transplantation. Macroencapsulation approaches are an appealing strategy, as they maximize graft retrievability and cell dosage within a single device; however, macroencapsulation devices face oxygen transport challenges as geometries increase from preclinical to clinical scales. Device design guided by computational approaches can facilitate graft oxygen availability to encapsulated cells in vivo but is limited without accurate measurement of oxygen levels within the transplant site and graft. In this study, we engineer pO₂ reporter composite hydrogels (PORCH) to enable spatiotemporal measurement of oxygen tension within macroencapsulati

SUBMITTER: Emerson AE 

PROVIDER: S-EPMC11239328 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature