Spatial genomic, biochemical and cellular mechanisms underlying meningioma heterogeneity and evolution.

ABSTRACT: Intratumor heterogeneity underlies cancer evolution and treatment resistance, but targetable mechanisms driving intratumor heterogeneity are poorly understood. Meningiomas are the most common primary intracranial tumors and are resistant to all medical therapies, and high-grade meningiomas have significant intratumor heterogeneity. Here we use spatial approaches to identify genomic, biochemical and cellular mechanisms linking intratumor heterogeneity to the molecular, temporal and spatial evolution of high-grade meningiomas. We show that divergent intratumor gene and protein expression programs distinguish high-grade meningiomas that are otherwise grouped together by current classification systems. Analyses of matched pairs of primary and recurrent meningiomas reveal spatial expansion of s

SUBMITTER: Lucas CG 

PROVIDER: S-EPMC11239374 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature