Association of obstructive sleep apnea syndrome with polycystic ovary syndrome through bidirectional Mendelian randomization.

ABSTRACT:

Background

Observational studies have established a link between polycystic ovary syndrome (PCOS) and obstructive sleep apnea syndrome (OSAS), with obesity being a significant confounding factor that complicates the understanding of causality. This study seeks to clarify the causal relationship by utilizing bidirectional two-sample Mendelian randomization (MR) analysis.

Methods

A bidirectional MR strategy was implemented to investigate the potential causal relationship between PCOS and OSAS. Instrumental variables (IVs) for PCOS were sourced from a dataset comprising 3,609 cases and 229,788 controls. For OSAS, statistical data were obtained from a genome-wide association study (GWAS) involving 38,998 subjects, alongside a control group of 336,659 individuals. Our MR analysis

SUBMITTER: Liu P 

PROVIDER: S-EPMC11239387 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature