The influence of PER3 VNTR genotypes on the age of onset in a group of bipolar I disorder patients: an exploratory study.

ABSTRACT:

Background

PER3 is a circadian gene that contains a variable number of tandem repeats (VNTR) which codifies for three genotypes: 4/4; 4/5; and 5/5 and is involved in non-visual response to light, a critical process associated with bipolar disorder onset. Benedetti et al. (Neurosci Lett 445(2):184-7) related this VNTR with bipolar disorder age of onset and linked genotype 5/5 with an earlier onset. In this study, we aimed to investigate these associations of PER3 VNTR genotypes with age of onset in a homogenous sample of German patients with bipolar I disorder through Kaplan-Meier curves.

Methods

45 patients were enrolled and divided into three groups according to PER3 VNTR genotypes. Recognizing common biological features, we built a combined group of -5 allele carriers (4/5

SUBMITTER: Barlattani T 

PROVIDER: S-EPMC11239620 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature