Atopic Dermatitis Complicated by Recurrent Eczema Herpeticum Is Characterized by Multiple, Concurrent Epidermal Inflammatory Endotypes.

ABSTRACT: A subgroup of patients with atopic dermatitis (AD) suffers from recurrent, disseminated herpes simplex virus skin infection, termed eczema herpeticum. To determine the transcriptional mechanisms of the skin and immune system pathobiology that underlie development of AD with eczema herpeticum (ADEH), we performed RNA-sequencing analysis of nonlesional skin (epidermis, dermis) from AD patients with and without a history of ADEH (ADEH⁺, n = 15; ADEH^-, n = 13) along with healthy controls (n = 15). We also performed RNA sequencing on participants' plasmacytoid dendritic cells infected in vitro with herpes simplex virus 1. ADEH⁺ patients exhibited dysregulated gene expression, limited in the dermis (14 differentially expressed genes) and more widespread in the ep

SUBMITTER: Jackson ND 

PROVIDER: S-EPMC11239700 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature