Modeling of a Bioengineered Immunomodulating Microenvironment for Cell Therapy.

ABSTRACT: Cell delivery and encapsulation platforms are under development for the treatment of Type 1 Diabetes among other diseases. For effective cell engraftment, these platforms require establishing an immune-protected microenvironment as well as adequate vascularization and oxygen supply to meet the metabolic demands of the therapeutic cells. Current platforms rely on 1) immune isolating barriers and indirect vascularization or 2) direct vascularization with local or systemic delivery of immune modulatory molecules. Supported by experimental data, here a broadly applicable predictive computational model capable of recapitulating both encapsulation strategies is developed. The model is employed to comparatively study the oxygen concentration at different levels of vascularization, transplanted ce

SUBMITTER: Capuani S 

PROVIDER: S-EPMC11239796 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature