Leptochelins A-C, Cytotoxic Metallophores Produced by Geographically Dispersed <i>Leptothoe</i> Strains of Marine Cyanobacteria.

ABSTRACT: Metals are important cofactors in the metabolic processes of cyanobacteria, including photosynthesis, cellular respiration, DNA replication, and the biosynthesis of primary and secondary metabolites. In adaptation to the marine environment, cyanobacteria use metallophores to acquire trace metals when necessary as well as to reduce potential toxicity from excessive metal concentrations. Leptochelins A-C were identified as structurally novel metallophores from three geographically dispersed cyanobacteria of the genus Leptothoe. Determination of the complex structures of these metabolites presented numerous challenges, but they were ultimately solved using integrated data from NMR, mass spectrometry and deductions from the biosynthetic gene cluster. The leptochelins are comprised of ha

SUBMITTER: Avalon NE 

PROVIDER: S-EPMC11240249 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature