Prognostic Evaluation of Piezo2 Channels in Mammary Gland Carcinoma.

ABSTRACT: In the last decade, a group of Ca²⁺ channels called Piezo were discovered, demonstrating a decisive role in the cellular response to mechanical stimuli and being essential in the biological behavior of cells regarding the extracellular compartment. Several investigations have suggested a potential role in carcinogenesis, with a tumor suppressor role in some cases but increased expression in several high-grade neoplasms. Regarding Piezo2 expression in mammary gland neoplasms, a protective role for Piezo2 was initially suggested, but a subsequent study demonstrated a relationship between Piezo2 expression and the highly aggressive triple-negative phenotype of breast carcinoma. A cohort of 125 patients with clinical follow-up was chosen to study Piezo2 expression and clarify its cl

SUBMITTER: Martin-Sanz R 

PROVIDER: S-EPMC11240440 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature