Integrative Analyses of Circulating Proteins and Metabolites Reveal Sex Differences in the Associations with Cardiac Function among DCM Patients.

ABSTRACT: Dilated cardiomyopathy (DCM) is characterized by reduced left ventricular ejection fraction (LVEF) and left or biventricular dilatation. We evaluated sex-specific associations of circulating proteins and metabolites with structural and functional heart parameters in DCM. Plasma samples (297 men, 71 women) were analyzed for proteins using Olink assays (targeted analysis) or LC-MS/MS (untargeted analysis), and for metabolites using LC MS/MS (Biocrates AbsoluteIDQ p180 Kit). Associations of proteins (n = 571) or metabolites (n = 163) with LVEF, measured left ventricular end diastolic diameter (LVEDD^measured), and the dilation percentage of LVEDD from the norm (LVEDD^{acc. to HENRY}) were examined in combined and sex-specific regression models. To disclose protein-metabolite

SUBMITTER: Hannemann A 

PROVIDER: S-EPMC11241450 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature