Association between Circulating T Cells and the Gut Microbiome in Healthy Individuals: Findings from a Pilot Study.

ABSTRACT: Though the microbiome's impact on immune system homeostasis is well documented, the effect of circulating T cells on the gut microbiome remains unexamined. We analyzed data from 50 healthy volunteers in a pilot trial of aspirin, using immunophenotyping and 16S rRNA sequencing to evaluate the effect of baseline T cells on microbiome changes over 6 weeks. We employed an unsupervised sparse canonical correlation analysis (sCCA) and used multivariable linear regression models to evaluate the association between selected T cell subsets and selected bacterial genera after adjusting for covariates. In the cross-sectional analysis, percentages of naïve CD4+ T cells were positively associated with a relative abundance of Intestinimonas, and the percentage of activated CD8+ T cells was invers

SUBMITTER: Vivek S 

PROVIDER: S-EPMC11241708 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature