Safety of embryo cryopreservation: insights from mid-term placental transcriptional changes.

ABSTRACT:

Background

In recent years, with benefits from the continuous improvement of clinical technology and the advantage of fertility preservation, the application of embryo cryopreservation has been growing rapidly worldwide. However, amidst this growth, concerns about its safety persist. Numerous studies have highlighted the elevated risk of perinatal complications linked to frozen embryo transfer (FET), such as large for gestational age (LGA) and hypertensive disorders during pregnancy. Thus, it is imperative to explore the potential risk of embryo cryopreservation and its related mechanisms.

Methods

Given the strict ethical constraints on clinical samples, we employed mouse models in this study. Three experimental groups were established: the naturally conceived (NC) group, th

SUBMITTER: Luo QY 

PROVIDER: S-EPMC11241961 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature